Recent Advances on the Machine Learning Methods in Identifying DNA Replication Origins in Eukaryotic Genomics
نویسندگان
چکیده
منابع مشابه
Making sense of eukaryotic DNA replication origins.
DNA replication is the process by which cells make one complete copy of their genetic information before cell division. In bacteria, readily identifiable DNA sequences constitute the start sites or origins of DNA replication. In eukaryotes, replication origins have been difficult to identify. In some systems, any DNA sequence can promote replication, but other systems require specific DNA seque...
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A new insight is revealed by Anglana et al. 128 kb of the single, primary (high frequency) oriGNA13. mary origin represses initiation at the secondary origins. Moreover, increasing the nucleotide pool by addition of DNA precursors to the culture medium reduces the frequency of initiation at secondary origins, whereas reducing the nucleotide pool by addition of hydroxyurea (a specific inhibitor ...
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DNA replication, one of the central events in the cell cycle, is the basis of biological inheritance. In order to be duplicated, a DNA double helix must be opened at defined sites, which are called DNA replication origins (ORIs). Unlike in bacteria, where replication initiates from a single replication origin, multiple origins are utilized in the eukaryotic genomes. Among them, the ORIs in budd...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2018
ISSN: 1664-8021
DOI: 10.3389/fgene.2018.00613